The median annual wage for pharmacists working in San Francisco, CA, sits at $177,410, per BLS survey data. It runs 27% above the national median of $139,410 for this occupation — pay here is notably stronger than the U.S. average. The middle 50% land between $164,560 and $220,120 — a 55,560 range that reflects differences in seniority, employer type, and specialization. The average (mean) of $184,540 comes in higher than the median, which usually means a share of high earners is pulling the average up. The catch: San Francisco is roughly in line with the national cost of living (cost index 100 against a 100 baseline), so that headline number buys less than it would elsewhere. On an hourly basis that is about $85.29, useful for comparing contract or part-time offers.

For context, the national median for pharmacists across all U.S. metros in our data is $139,410.