LocalSalaryHub Salary Report
Nurse Practitioners in Greenville, SC · Generated June 17, 2026
Nurse Practitioners Salary in Greenville, SC $119,280/yr
$119,280
Mean: $118,850
~$93,038 est. take-home
$57.35
Based on 2,080 hrs/yr
100
100 = national avg
Very affordable
Affordability score: 100/100
$5,458/mo
68%
Salary Distribution
Where the median falls between the 25th and 75th percentile.
25th %
$110,030
Median
$119,280
75th %
$129,900
Median is in the 47th percentile of the typical range
Nurse Practitioners in other SC cities
Compare the same occupation across cities in SC.
About Nurse Practitioners salaries in Greenville, SC
Nurse Practitioners in Greenville, SC earn a median of $119,280 per year, based on BLS Occupational Employment and Wage Statistics data. The mean salary is $118,850, which tends to skew higher because a small number of high earners pull the average up.
Most nurse practitioners in this area earn between $110,030 and $129,900. Where you land depends on experience, employer type, and whether you have in-demand specializations.
That works out to roughly $57.35 per hour assuming a standard 2,080-hour work year. Actual hourly pay may differ for part-time or contract roles.
Career Outlook
40% growth — one of the fastest-growing jobs in the entire country. More than half of U.S. states now let NPs practice independently without a physician overseeing them. That, plus a chronic shortage of primary care doctors, especially in rural areas, is pushing demand through the roof.
Worth knowing: In full-practice-authority states (like Arizona, Colorado, Oregon), NPs are opening their own clinics. It's one of the best ROI paths in healthcare: 2–3 years of additional schooling can double or triple an RN salary.
Nurse Practitioners Jobs in Greenville, SC
Median: $119,280/yr — browse openings that fit.
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Frequently Asked Questions
What is the average salary for a nurse practitioners in Greenville?▾
The median — where half earn more and half earn less — is $119,280. The average (mean) is $118,850, which is higher because top earners pull it up.
How much does a nurse practitioners make per hour in Greenville?▾
About $57.35/hour, based on a standard 2,080-hour work year. Part-time or overtime hours will change the actual rate.
What is the salary range for nurse practitioners in Greenville?▾
The middle 50% earn between $110,030 and $129,900. Below $110,030 is typically entry-level; above $129,900 usually means significant experience or specialized skills.
Salary Conversion Table
How does $119,280 per year break down across different time periods?
| Period | Gross | Est. Take-Home |
|---|---|---|
| Yearly | $119,280 | $93,038 |
| Monthly | $9,940 | $7,753 |
| Biweekly | $4,588 | $3,578 |
| Weekly | $2,294 | $1,789 |
| Hourly (40h/wk) | $57.35 | $44.73 |
| Hourly (35h/wk) | $65.54 | $51.12 |
| Hourly (30h/wk) | $76.46 | $59.64 |
| Daily (8h) | $459 | $358 |
Take-home estimates use an effective tax rate of 22%. Actual amounts vary by filing status, deductions, and state tax.
Nurse Practitioners: Highest-Paying Cities in the U.S.
Top 10 cities nationwide for nurse practitioners, based on BLS median salary data.
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See more salary data
More pages tied to this occupation and region.
- Nurse Practitioners salaries nationwide — the national median and the highest-paying metros for nurse practitioners across all states.
- All SC salary data — every occupation we cover in SC, ranked by median pay, plus the cities that pay the most.
- Nurse Practitioners in San Jose, CA — the top-paying city for nurse practitioners in our dataset, in case you are weighing a move out of Greenville.
- Pharmacists salary overview — a closely related role (same SOC major group) with a national median of $142,697.